Invitrogen™ AXIN1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518024

Catalog No. PIPA518024

Description

This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

Specifications

• Antigen: AXIN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AXIN1
• Gene Alias: AI316800; AXIN; axin 1; Axin1; axin-1; Axis inhibition protein 1; axis inhibitor 1; Fu; fused; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; Kb; Ki; kinky; knobbly; LA16c-314G4.3; MGC52315; PPP1R49; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 8312
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O15169
• Gene Symbols: AXIN1
• Immunogen: Synthetic peptide sequence (FEEKIIGKVEKVD) corresponding to the C-terminus amino acids of AXIN1 (aa 850-862).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG