AXIN1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 165411AP150UL

Catalog No. 50-173-1016

Description

Proteintech's AXIN1 antibody 16541-1-AP is a rabbit polyclonal antibody raised against the N-terminus of human AXIN1.

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

Specifications

• Antigen: AXIN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AXIN1
• Gene Alias: AXIN, axin 1, AXIN1, Axis inhibition protein 1, hAxin
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8312
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O15169
• Gene Symbols: AXIN1
• Immunogen: AXIN1 Fusion Protein Ag9858
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG