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Invitrogen™ AXIN2 Polyclonal Antibody
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Catalog No. PIPA5102622
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100 μL
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PIPA5102622 100 μL
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Catalog No. PIPA5102622 Supplier Invitrogen™ Supplier No. PA5102622
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total AXIN2.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AXIN2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene AXIN2
Gene Accession No. O70240, O88566, Q9Y2T1
Gene Alias Axi1; axil; axin 2; Axin like protein; axin2; axin-2; Axin-like protein; Axis inhibition protein 2; conductin; DKFZp781B0869; MGC10366; MGC126582; ODCRCS
Gene Symbols AXIN2
Host Species Rabbit
Immunogen A synthesized peptide derived from human AXIN2(Accession Q9Y2T1), corresponding to amino acid residues G41-G91.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12006, 29134, 8313
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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