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Invitrogen™ Axl Recombinant Rabbit Monoclonal Antibody (109), Invitrogen™
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Catalog No. PIMA543059
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PIMA543059 100 μL
PIMA543532 50 μL
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Catalog No. PIMA543059 Supplier Invitrogen™ Supplier No. MA543059
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Mouse AXL

AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Axl
Applications ELISA
Classification Recombinant Monoclonal
Clone 109
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene AXL
Gene Accession No. Q00993
Gene Alias Adhesion-related kinase; AI323647; ARK; AXL; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming sequence/gene; AZF1; JTK11; oncogene AXL; sAXL; soluble AXL; Tyro7; Tyrosine-protein kinase receptor UFO; Ufo; ufo oncogene homolog
Gene Symbols AXL
Host Species Rabbit
Immunogen Recombinant Mouse AXL Protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26362
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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