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Invitrogen™ Axonal Growth Cones Monoclonal Antibody (2G13)
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Catalog No. MA180893
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2 mL
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MA180893 2 mL
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Catalog No. MA180893 Supplier Invitrogen™ Supplier No. MA180893
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Description

Mouse Monoclonal Antibody

This product does not require protein digestion pre-treatment of paraffin embedded sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin embedded sections. Mouse anti Growth Cone antibody, clone 2G13 recognizes a protein originally termed 2G13P which is localized to growth cones.

This protein was originally termed 2G13P, which is localized to growth cones. Subsequent investigation has identified this protein to be 40S ribosomal protein SA, also known as 37 kDa laminin receptor precursor or Laminin receptor 1 (Baloui et al. 2004). 40S ribosomal protein SA is a 296 amino acid ~37kDa membrane, cytoplasmic and nuclear protein required for the assembly and/or stability of the 40S ribosomal subunit. In vertebrate evolution the molecule has acquired a secondary function as a laminin receptor (UniProt: P50890). In growth cones expression is notable particularly in filopodia and lamellipodia in developing rat CNS and embryonic neurons in culture (Stettler et al. 1999). 40S ribosomal protein SA interacts with the filamentous actin cytoskeleton and therefore may be involved in growth cone motility (Stettler et al. 1999).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Axonal Growth Cones
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 2G13
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant with 5-10% FBS and 0.09% sodium azide
Gene Alias 2G13P
Host Species Mouse
Immunogen Embryonic chick tectal membranes.
Quantity 2 mL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse, Rat, Chicken
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgM
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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