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Tocris™ AY 254
SDP

Catalog No. 70341 Shop All Novus Biologicals Products
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70-341 1 mg
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Catalog No. 70-341 Supplier Tocris™ Supplier No. 7034/1

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Description

Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.

Specifications

CAS 2093408-03-6
Quantity 1 mg
Target Protease-Activated Receptor Agonists
Molecular Formula C30H49N9O6
Purity 0.95
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