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Tocris Bioscience™ AZ 1729
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Catalog No. 682610
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10 mg
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68-261-0 10 mg
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Catalog No. 68-261-0 Supplier Tocris Bioscience™ Supplier No. 6826/10
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Description

FFA2 allosteric agonist; displays bias for the Gi signaling pathway

AZ 1729 is a FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro.

Specifications

Chemical Name or Material 4-Fluoro-N-[3-[2-[(aminoiminomethyl)amino]-4-methyl-5-thiazolyl]phenyl]benzamide
CAS 2016864-46-1
Quantity 10 mg
Target Free Fatty Acid Receptor Agonists
Molecular Formula C18H16FN5OS
Formula Weight 2323
Purity 98%
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