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Tocris Bioscience™ AZ 3137
SDP

Catalog No. 88335 Shop All R&D Systems Products
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88-335 5 mg
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Catalog No. 88-335 Supplier Tocris Bioscience™ Supplier No. 8833/5
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Description

Potent and selective AR and AR L702H Degrader, orally bioavailable

AZ 3137 is a potent and selective androgen receptor (AR) Degrader (PROTAC®)(DC50 = 22 nM in LNCaP cells). AZ 3137 can degrade L702H mutant AR (DC50 = 158 nM). AZ 3137 inhibits the proliferation of LNCaPs cells (GI50 = 74 nM). AZ 3137 inhibits AR signaling in vitro and tumor growth in vivo in a mouse prostate cancer xenograft model. AZ 3137 is orally bioavailable.

Specifications

Chemical Name or Material 4-[4-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-7-methoxy-1-oxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile
CAS 2960179-55-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C43H47F4N7O4
Purity 98%
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