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Tocris Bioscience™ AZ 628
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Catalog No. 483610
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Catalog No. Quantity
48-361-0 10 mg
48-365-0 50 mg
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Catalog No. 48-361-0 Supplier Tocris Bioscience™ Supplier No. 4836/10
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Description

Potent Raf kinase inhibitor

Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.

Chemical Identifiers

CAS 878739-06-1
Molecular Formula C27H25N5O2

Specifications

Quantity 10 mg
Formula Weight 451.52
Purity >98%
Molecular Weight (g/mol) 451.53
Chemical Name or Material AZ 628

Safety and Handling

Recommended Storage Store at +4°C
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