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  8. AZ 628, Tocris Bioscience™

AZ 628, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
878739-06-1
C27H25N5O2
451.53
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide,3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl benzamide,3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino phenyl benzamide,3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide,3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide,b1e,benzamide, 3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl,3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide
11676786
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C
This item is not returnable. View return policy
878739-06-1
C27H25N5O2
451.53
ZGBGPEDJXCYQPH-UHFFFAOYSA-N
3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide,3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl benzamide,3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino phenyl benzamide,3-2-cyanopropan-2-yl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide,3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxoquinazolin-6-yl amino phenyl benzamide,b1e,benzamide, 3-1-cyano-1-methylethyl-n-3-3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl amino-4-methylphenyl,3-1-cyano-1-methylethyl-n-4-methyl-3-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl amino phenyl benzamide
11676786
3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl)amino]phenyl]benzamide
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

Description

Potent Raf kinase inhibitor

Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
Quantity 10mg
Formula Weight 451.52
Percent Purity >98%
Chemical Name or Material AZ 628

Safety and Handling

Recommended Storage : Store at +4°C