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Tocris Bioscience™ AZ Dyrk1B 33
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Catalog No. 563210
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10 mg
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Catalog No. Quantity
56-321-0 10 mg
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Catalog No. 56-321-0 Supplier Tocris Bioscience™ Supplier No. 5632/10
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Description

Potent and selective Dyrk1B kinase inhibitor

AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 (Cat. No 5232); displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Specifications

Chemical Name or Material 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine
CAS 1679330-37-0
Quantity 10 mg
Solubility Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Molecular Formula C19H16N4
Formula Weight 300.36
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >98%

For Research Use Only.

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