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  5. Tocris Bioscience™ AZ1 USP25/28 inhibitor

Tocris Bioscience™ AZ1 USP25/28 inhibitor
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Catalog No. 784510
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78-451-0 10 mg
78-455-0 50 mg
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Catalog No. 78-451-0 Supplier Tocris Bioscience™ Supplier No. 7845/10
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Description

Selective USP25 and USP28 inhibitor

AZ1 USP25/28 inhibitor is a selective inhibitor of USP28 (IC50 = 0.6 μM, Kd= 0.2 - 3.7 μM) and USP25 (IC50 = 0.7 μM). AZ1 USP25/28 inhibitor exhibits selectivity for USP25 and USP28 over other DUB family members. The compound dose-dependently reduces c-Myc levels in colon carcinoma cells in vitro and induces cell death (EC50 values are 18 - 20 μM). In a mouse Alzheimer's disease model, AZ1 USP25/28 inhibitor reduces amyloid burden, attenuates microglial activation and improves synaptic and cognitive function.

Specifications

Chemical Name or Material 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
CAS 2165322-94-9
Quantity 10 mg
Target USP28
Molecular Formula C17H16BrF4NO2
Purity 0.98
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