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Tocris Bioscience™ AZD 1208
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Catalog No. 631010
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10 mg
50 mg
Catalog No. Quantity
63-101-0 10 mg
63-105-0 50 mg
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Catalog No. 63-101-0

Supplier: Tocris Bioscience™ 6310/10

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Description

Potent pan Pim kinase inhibitor

AZD 1208 is a potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. AZD 1208 downmodulates the expression of Mayaro virus (MAYV) structural protein E1 and non-structural protein 1 (nsP1), and it reduces MAYV replication in a dose-dependent manner in HeLa or HDFs cells. Chemosensitizer.

Specifications

Chemical Name or Material (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
CAS 1204144-28-4
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C21H21N3O2S
Formula Weight Observed MW: 379.48
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