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Tocris Bioscience™ AZD 2858
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Catalog No. 765010
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76-501-0 10 mg
76-505-0 50 mg
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Catalog No. 76-501-0 Supplier Tocris Bioscience™ Supplier No. 7650/10
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Description

Highly potent GSK-3 inhibitor; inhibits tau phosphorylation

AZD 2858 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 0.9 and 5 nM for GSK-3α and GSK-3β, respectively). AZD 2858 inhibits tau phosphorylation in vitro (IC50 = 76 nM), improves fracture healing and increases bone mass in rodent models of bone fracture. Also activates Wnt signaling in vitro and in vivo. Brain permeable and orally bioavailable.

Specifications

Chemical Name or Material 3-Amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide
CAS 486424-20-8
Quantity 10 mg
Target Glycogen Synthase Kinase Inhibitors
Molecular Formula C21H23N7O3S
Purity 0.98
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