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  5. Tocris Bioscience™ AZD 5363

Tocris Bioscience™ AZD 5363
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Catalog No. 69785
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25 mg
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Catalog No. Quantity
69-785 5 mg
69-782-5 25 mg
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Catalog No. 69-785 Supplier Tocris Bioscience™ Supplier No. 6978/5
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Description

Potent pan-AKT inhibitor

AZD 5363 is a potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines in vitro, particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances in vivo antitumor effects of Docetaxel (Cat. No. 4056) and Lapatinib (Cat. No. 6811). Orally bioavailable.

Specifications

Synonym Capivasertib
Quantity 5 mg
Molecular Formula C21H25ClN6O2
Formula Weight 428.92
Product Type Inhibitor
Purity 98%
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