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  5. Tocris Bioscience™ AZD 7762 hydrochloride

Tocris Bioscience™ AZD 7762 hydrochloride

Catalog No. 519950
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50 mg
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Catalog No. Quantity
51-995-0 50 mg
51-991-0 10 mg
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Catalog No. 51-995-0 Supplier Tocris Bioscience™ Supplier No. 5199/50
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Description

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).

Specifications

Quantity 50 mg
Product Type AZD 7762 hydrochloride
Purity >98%
Molecular Weight (g/mol) 398.88
Inhibitors AZD 7762 hydrochloride

For Research Use Only

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