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  6. Invitrogen™ Azurocidin Recombinant Rabbit Monoclonal Antibody (421), Invitrogen™

Invitrogen™ Azurocidin Recombinant Rabbit Monoclonal Antibody (421), Invitrogen™

Catalog No. PIMA543368
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Catalog No. PIMA543368 Supplier Invitrogen™ Supplier No. MA543368
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Human Azurocidin/CAP37

Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C. albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta 2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Azurocidin
Applications ELISA
Classification Recombinant Monoclonal
Clone 421
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene AZU1
Gene Accession No. P20160
Gene Alias AZAMP; AZU; AZU1; Azurocidin; azurocidin 1; CAP37; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37; HBP; Heparin-binding protein; hHBP; HUMAZUR; NAZC; neutrophil azurocidin; pHBP
Gene Symbols AZU1
Host Species Rabbit
Immunogen Recombinant Human Azurocidin/CAP37 Protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 566
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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