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Tocris Bioscience™ B 973B
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Catalog No. 676450
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67-645-0 50 mg
67-641-0 10 mg
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Catalog No. 67-645-0 Supplier Tocris Bioscience™ Supplier No. 6764/50
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Description

Positive allosteric modulator of α7 nAChRs; analgesic

B 973B is a positive allosteric modulator of α7 nAChRs (EC50 ∽0.3 μM); active enantiomer. Increases potency of acetylcholine (EC50 values are 0.007 mM and 0.3 mM in the presence and absence of B 937B, respectively). Potentiates peak acetylcholine-induced currents 6-fold relative to maximal acetylcholine, and slows channel desensitization, resulting in a 6900-fold increase in charge transfer. Decreases paw edema in vivo. Analgesic.

Specifications

Chemical Name or Material 3,4-Difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]benzenepropanamide
CAS 2244989-34-0
Quantity 50 mg
Molecular Formula C24H26F2N6O
Purity 98%
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