Invitrogen™ B-Raf (K601E Mutant) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143383

Catalog No. PIPA5143383

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial.

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes A pseudogene of this gene has been identified on the X chromosome.

Specifications

• Antigen: B-Raf (K601E Mutant)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: P29466, P48729, Q8N752
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 122011, 1452, 834
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.54 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7
• Gene Alias: B-raf; B-Raf proto-oncogene, serine/threonine kinase; BRAF1; B-RAF1; NS7; RAFB1
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding mutant K601E of human B-Raf. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG