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B-Raf Monoclonal Antibody (1H12), Invitrogen™

Catalog No. PIMA515495
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100 μL
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Catalog No. Quantity
PIMA515495 100 μL
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Catalog No. PIMA515495 Supplier Thermo Scientific Supplier No. MA515495

Description

Mouse Monoclonal Antibody

MA5-15495 targets BRAF in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human and mouse samples. The MA5-15495 immunogen is purified recombinant fragment of human BRAF expressed in E. Coli.<br>. MA5-15495 detects BRAF which has a predicted molecular weight of approximately 87kDa.

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in B-Raf have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for B-Raf.
TRUSTED_SUSTAINABILITY

Specifications

Antigen B-Raf
Applications ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 1H12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene BRAF
Gene Accession No. P15056, P28028
Gene Alias 94 kDa B-raf protein; 9930012E13Rik; AA120551; AA387315; AA473386; Braf; B-raf; B-raf protein; B-raf protein isoform 1; B-raf protein isoform 2; B-Raf proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf proto-oncogene, serine/threonine kinase; Braf transforming gene; BRAF1; B-RAF1; Braf2; Braf-2; C230098H17; C87398; C-RMIL; D6Ertd631e; FLJ95109; MGC126806; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; p94; Proto-oncogene B-Raf; proto-oncogene c-Rmil; RAFB1; RMIL; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
Gene Symbols BRAF
Host Species Mouse
Immunogen Purified recombinant fragment of human BRAF expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109880, 673
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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