Invitrogen™ B-Raf Polyclonal Antibody

Chicken Polyclonal Antibody

Supplier:  Invitrogen™ PA5114457

Catalog No. PIPA5114457

Description

Positive controls that may be used include: Human Brain Tissue Lysate, Cat. No. 1210-293 Cell Lysate, Cat. No. 1224-Daudi Cell Lysate, Cat. No. 1204-K562 Cell Lysate.

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in B-Raf have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for B-Raf.

Specifications

• Antigen: B-Raf
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BRAF
• Gene Alias: 94 kDa B-raf protein; 9930012E13Rik; AA120551; AA387315; AA473386; Braf; B-raf; B-raf protein; B-raf protein isoform 1; B-raf protein isoform 2; B-Raf proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase (p94); B-Raf proto-oncogene, serine/threonine kinase; Braf transforming gene; BRAF1; B-RAF1; Braf2; Braf-2; C230098H17; C87398; C-RMIL; D6Ertd631e; FLJ95109; MGC126806; murine sarcoma viral (v-raf) oncogene homolog B1; NS7; p94; Proto-oncogene B-Raf; proto-oncogene c-Rmil; RAFB1; RMIL; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase B-raf; Serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
• Host Species: Chicken
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 109880, 114486, 673
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Functional Assay, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P15056, P28028
• Gene Symbols: BRAF
• Immunogen: Anti-B-raf antibody was raised against a peptide corresponding to 18 amino acids near the center of human B-raf. The immunogen is located within amino acids 330 - 380 of B-raf.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgY

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov