Invitrogen™ B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (RM8), Biotin

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544555

Catalog No. PIMA544555

Description

This antibody reacts to the Histone H3.3 G34R mutant. No cross reactivity with wild type Histone H3.3.

This gene, B-RAF/BRAF, encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.

Specifications

• Antigen: B-Raf (V600E)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: P15056
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 673
• Content And Storage: -20°C
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: RM8
• Conjugate: Biotin
• Gene: BRAF
• Gene Symbols: BRAF
• Immunogen: A peptide corresponding to BRAF V600E mutant. The immunogen range is a synthetic peptide within amino acids 550-650 of Akt with V600E mutant.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG