B220/CD45R Antibody (PTPRC/1460), PE/Cy7, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP254465PECY7

Catalog No. N254465PEC7

Description

B220/CD45R Monoclonal specifically detects B220/CD45R in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: B220/CD45R
• Classification: Monoclonal
• Conjugate: PE-Cyanine7
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: PTPRC
• Immunogen: Human B-lymphocytes (Uniprot: P08575)
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
• Content And Storage: Store at 4°C in the dark. Do not freeze.

• Applications: Flow Cytometry
• Clone: PTPRC/1460
• Dilution: Flow Cytometry
• Gene Alias: B220, CD45 antigen, CD45R, EC 3.1.3.48, L-CA, LY5, protein tyrosine phosphatase, receptor type, C, receptor-type tyrosine-protein phosphatase C, T200 glycoprotein, T200 leukocyte common antigen, T200receptor type, c polypeptide
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Adaptive Immunity, Cell Biology, Cellular Markers, Cellular Signaling, Cytokine Research, Glia Markers, Hematopoietic Stem Cell Markers, Immunology, Immunophenotyping, MAP Kinase Signaling, Mast Cell Markers, Mesenchymal Stem Cell Markers, Microglia Markers, Modulation of DNA Pools, Myeloid Cell Markers, Myeloid derived Suppressor Cell, Neurodegeneration, Neuronal Cell Markers, Neuroscience, Signal Transduction, Stem Cell Markers
• Gene ID (Entrez): 5788.0
• Target Species: Human
• Isotype: IgG1 κ