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B2M Mouse anti-Human, Clone: OTI1A7, lyophilized, TrueMAB™
SDP

Catalog No. 501666598
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100 μg
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50-166-6598 100 μg
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Catalog No. 50-166-6598 Supplier OriGene Supplier No. CF803617
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predomitly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

Specifications

Antigen B2M
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1A7
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene B2M
Gene Accession No. P61769
Gene Alias IMD43
Gene Symbols B2M
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 21-119 of human B2M produced in SF9 cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 567
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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