Invitrogen™ B3GNT1 Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547860

Catalog No. PIPA547860

Description

In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) B4GalT1 and rhB3GNT 2 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O- mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha- dystroglycan (DAG1).

Specifications

• Antigen: B3GNT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: B4GAT1
• Gene Alias: 1500032M01Rik; B3GNT1; B3GN-T1; B3GNT1 (HGNC:15685); B3gnt6; B4GAT1; beta-1,3-N-acetylglucosaminyltransferase bGnT-6; beta-1,4-glucuronyltransferase 1; BETA3GNT1; BETA3GNTI; EC 2.4.1.149; I-beta-1,3-N-acetylglucosaminyltransferase; iGAT; iGNT; MDDGA13; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
• Host Species: Sheep
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108902, 11041
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O43505, Q8BWP8
• Gene Symbols: B4GAT1
• Immunogen: CHO-derived recombinant human beta-1,3-N-acetylglucosaminyltransferase 1/B3GNT1 Asp43-Cys415.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG