B7-1/CD80 Antibody (IDEC-114 (Galiximab)), Allophycocyanin, Novus Biologicals™

Rabbit Monoclonal Antibody

Supplier:  Novus Biologicals NBP281100APC

Catalog No. NB016073

Description

B7-1/CD80 Monoclonal specifically detects B7-1/CD80 in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: B7-1/CD80
• Classification: Monoclonal
• Conjugate: APC
• Formulation: PBS
• Gene Symbols: CD80
• Immunogen: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant B7-1/CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)
• Quantity: 0.1 mL
• Research Discipline: Adaptive Immunity, B Cell Development and Differentiation Markers, Cytokine Research, Immunology, Signal Transduction
• Gene ID (Entrez): 941
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry
• Clone: IDEC-114 (Galiximab)
• Dilution: Flow Cytometry
• Gene Alias: Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen), CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80
• Host Species: Rabbit
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to B7-1/CD80. B7-1/CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. B7-1/CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG λ