B7-H3/CD276 Recombinant Rabbit Monoclonal Antibody (BLR025F), Bethyl Laboratories

Rabbit Recombit Monoclonal Antibody

Supplier:  Bethyl Laboratories, Inc A700025T

Catalog No. 50-157-2644

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.

Specifications

• Antigen: B7-H3/CD276
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: CD276
• Gene Alias: PSEC0249; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2; B7 homolog 3; CD276 antigen; costimulatory molecule; HB7H3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80381
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: BLR025F
• Formulation: BBS with 0.09% sodium azide; pH 8.2
• Gene Accession No.: Q5ZPR3
• Gene Symbols: CD276
• Immunogen: between 484 to 534
• Quantity: 10 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG