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B7-H3/CD276 Recombinant Rabbit Monoclonal Antibody (BLR025F), Bethyl Laboratories

Catalog No. 501572644
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50-157-2644 10 μL
50-157-2643 100 μL
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Catalog No. 50-157-2644 Supplier Bethyl Laboratories, Inc Supplier No. A700025T
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Description

Rabbit Recombit Monoclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.

Specifications

Antigen B7-H3/CD276
Applications Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone BLR025F
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene CD276
Gene Accession No. Q5ZPR3
Gene Alias PSEC0249; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2; B7 homolog 3; CD276 antigen; costimulatory molecule; HB7H3
Gene Symbols CD276
Host Species Rabbit
Immunogen between 484 to 534
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80381
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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