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B7-H4 Monoclonal Antibody (H74), Super Bright™ 600, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$476.00
Specifications
| Antigen | B7-H4 |
|---|---|
| Clone | H74 |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
63-594-942
|
Invitrogen™
63594942 |
100 Tests |
Each of 1 for $476.00
|
|
|||||
Description
The H74 monoclonal antibody was generated and reacts with human B7-S1, also known as B7-H4 and B7x. Cross reactivity of this antibody to other proteins has not been determined. B7S1 is a newly discovered member of the B7 family. It is speculated that the
B7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).Specifications
| B7-H4 | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| Q7Z7D3 | |
| IgG1 κ | |
| 4°C, store in dark, DO NOT FREEZE! |
| H74 | |
| Flow Cytometry | |
| Super Bright 600 | |
| Mouse | |
| Human | |
| 79679 | |
| Primary | |
| Antibody |
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