B7-H7/HHLA2 Mouse anti-Human, Alexa Fluor 594, Clone: 907812, R&D Systems™
Mouse Monoclonal Antibody
Manufacturer: R&D Systems FAB80841T025
DescriptionB7-H7, also known as HHLA2 (HERV-H LTR-associating 2), is a member of the B7 family of immune regulatory proteins (1, 2). Mature human B7-H7 consists of a 322 amino acid (aa) extracellular domain (ECD) with three immunoglobulin-like domains, a 21 aa transmembrane segment, and a 49 aa cytoplasmic domain (3-5).B7-H7 is constitutively expressed on monocytes and is up-regulated by LPS and IFN-γ stimulation. It is expressed on LPS/IFN-γ treated B cells but not on resting B cells (5). B7-H7 binds to cell surface determinants on resting and mature T cells, B cells, and monocytes as well as on immature and mature dendritic cells (5). Soluble B7-H7 inhibits the proliferation of activated CD4+ and CD8+ T cells and their production of IFN-γ, TNF-α, IL-5, IL-10, IL-13, IL-17A, and IL-22 (5).
|Flow Cytometry 5 uL/10^6 cells|
|B7H7, HERV-H LTR-associating 2, HERV-H LTR-associating protein 2, HHLA2, Human endogenous retrovirus-H long terminal repeat-associating protein 2|
|Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.|
|Detects human B7-H7/HHLA2 in direct ELISAs.|
|Alexa Fluor 594|
|Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide|
|Human embryonic kidney cell line HEK293-derived human B7-H7/HHLA2 Met1-Asn344 Accession # Q9UM44|
|Protein A or G purified from hybridoma culture supernatant|
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