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BABAM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, liquid, OriGene
SDP

Catalog No. 501684765
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50-168-4765 100 μL
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Catalog No. 50-168-4765 Supplier OriGene Supplier No. TA890052
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Description

Rabbit Polyclonal Antibody

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36.

Specifications

Antigen BABAM1
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene BABAM1
Gene Accession No. Q3UI43, Q5XIJ6, Q9NWV8
Gene Alias C19orf62, HSPC142, MERIT40, NBA1
Gene Symbols Babam1
Host Species Rabbit
Immunogen Recombit protein of human BABAM1
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 290631, 29086, 68251
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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