Invitrogen™ BACE1 Recombinant Rabbit Monoclonal Antibody (7C5T7)

Catalog No.	Quantity
PIMA535126	100 μL

Catalog No. PIMA535126

Supplier: Invitrogen™ MA535126

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: FYVVFDRARK RIGFAVSACH VHDEFRTAAV EGPFVTLDME DCGYNIPQTD ESTLMTIAYV MAAICALFML PLCLMVCQWR CLRCLRQQHD DFADDISLLK.

BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a Swedish mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Specifications

• Antigen: BACE1
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 7C5T7
• Concentration: 1.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: BACE1
• Gene Accession No.: P56817, P56818, P56819
• Gene Alias: APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409
• Gene Symbols: BACE1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 402-501 of human BACE1 (P56817).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23621, 23821, 29392
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG