Invitrogen™ BACE2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1753

Catalog No. PA1753

Description

PA1-753 detects human beta-secretase 2 (BACE2) from transfected cells and rat and mouse samples. PA1-753 has been successfully used in Western blot and ICC/IF procedures. By Western blot this antibody detects an ~58 kDa protein representing BACE2 from SY-SY5Y cells overexpressing the human gene. The PA1-753 immunizing peptide corresponds to amino acid residues 441-457 from human BACE2. This sequence is completely conserved in mouse. The PA1-753 immunizing peptide (Cat. # PEP-166) is available for use in neutralization and control experiments.

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.

Specifications

• Antigen: BACE2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BACE2
• Gene Alias: 1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25825, 288227, 56175
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q6IE75, Q9JL18, Q9Y5Z0
• Gene Symbols: BACE2
• Immunogen: Synthetic Peptide: V(441) S E I S G P F S T E D I A S N C(457).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG