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BACE2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501980911
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100 μL
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50-198-0911 100 μL
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Catalog No. 50-198-0911 Supplier Bioss Supplier No. BS10494R
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Description

Rabbit Polyclonal Antibody

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.

Specifications

Antigen BACE2
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene BACE2
Gene Accession No. Q9Y5Z0
Gene Alias 1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852
Gene Symbols BACE2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human BACE2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25825
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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