BACE2 Chimeric Recombinant Mouse Monoclonal Antibody (1/ 9), Invitrogen™

Mouse Recombinant Monoclonal Antibody

Supplier:  Thermo Scientific MA547981

Catalog No. PIMA547981

Description

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.

Specifications

• Antigen: BACE2 Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: Q9Y5Z0
• Gene Symbols: BACE2
• Immunogen: Human BACE2 244-333.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Clone: 1/ 9
• Conjugate: Unconjugated
• Gene: BACE2
• Gene Alias: 1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25825
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Isotype: IgG1 κ