Bacillus anthracis Spore Antigen Monoclonal Antibody (SA26), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA121719

Catalog No. PIMA121719

Description

MA1-21719 detects Bacillus anthracis spore antigen in Bacteria samples.

Anthrax toxin is a three-protein exotoxin secreted by virulent strains of the bacterium Bacillus anthracis, the causative agent of anthrax. Anthrax toxin is composed of a cell-binding protein, known as protective antigen (PA), and two enzyme components, called edema factor (EF) and lethal factor (LF). These three protein components act together to impart their physiological effects. Assembled complexes containing the toxin components are endocytosed. In the endosome, the enzymatic components of the toxin translocate into the cytoplasm of a target cell. Once in the cytosol, the enzymatic components of the toxin disrupts various immune cell functions, namely cellular signaling and cell migration. The toxin may even induce cell lysis, as is observed for macrophage cells. Anthrax toxin allows the bacteria to evade the immune system, proliferate, and μgtimately kill the host animal. Research on anthrax toxin also provides insight into the generation of macromolecular assemblies, and on protein translocation, pore formation, endocytosis, and other biochemical processes.

Specifications

• Antigen: Bacillus anthracis Spore Antigen
• Classification: Monoclonal
• Concentration: 4.7 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Bacteria
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Western Blot
• Clone: SA26
• Conjugate: Unconjugated
• Gene Alias: Anthrax Spore; B. anthracis Spore
• Immunogen: Bacillus anthracis spore extract.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4° C, do not freeze
• Form: Liquid

Safety and Handling

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