Invitrogen™ BAF53A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114819

Catalog No. PIPA5114819

Description

Antibody detects endogenous levels of total ACTL6A.

BAF53A is a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

Specifications

• Antigen: BAF53A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Actl6a
• Gene Alias: 2810432C06Rik; 53 kDa BRG1-associated factor A; actin like 6A; actin-like 6; actin-like 6A; actin-like 6B; actin-like protein 6A; actin-related protein 4; actin-related protein Baf53a; Actl6; Actl6a; ACTL6B; AI851094; ARP4; ArpNbeta; ARPN-BETA; BAF complex 53 kDa subunit; BAF53; Baf53a; BAF53B; BRG1/brm-associated factor 53A; BRG1-associated factor 53A; C79802; hArpN alpha; hArpN beta; INO80 complex subunit K; INO80K; MGC5382; MGC5382 Arp4; RGD1307747
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361925, 56456, 86
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O96019, Q9Z2N8
• Gene Symbols: Actl6a
• Immunogen: A synthesized peptide derived from human ACTL6A(Accession O96019), corresponding to amino acid residues L217-L267.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov