Bafilomycin A1, Thermo Scientific Chemicals

Description

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity.

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases

• It is a macrolide antibiotic, and shows fungicide activity

Application

• Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity

• It can be immunosuppressive

• It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes

• It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)

Specifications

• Type: Bafilomycin A1
• Physical Form: Oil or Film
• CAS: 88899-55-2
• Molecular Formula: C35H58O9
• MDL Number: MFCD06795130
• Beilstein: 4730700
• Solubility Information: Soluble in methanol,ethanol,acetone and chloroform. Insoluble in water.
• InChI Key: XDHNQDDQEHDUTM-XRCNURIOSA-N
• SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
• IUPAC Name: (3Z,5E,7S,8R,9R,11Z,15R,16S)-16-[(2R,3S,4R)-4-[(2S,4S,5R,6S)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
• Molecular Weight (g/mol): 622.84
• PubChem CID: 133268469
• Formula Weight: 622.83
• Color: Colorless
• Quantity: 1 mg
• Chemical Name or Material: Bafilomycin A1

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
RTECSNumber	RN9781000
TSCA	No
storageNote1	-30° to -10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only