Invitrogen™ BAG4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109441

Catalog No. PIPA5109441

Description

Immunogen sequence: MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ SLNSYTNGAY.

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.

Specifications

• Antigen: BAG4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BAG4
• Gene Alias: 2410112I15Rik; BAG cochaperone 4; BAG family molecular chaperone regulator 4; BAG4; BAG-4; BAG-family molecular chaperone regulator-4; BCL2 associated athanogene 4; Bcl-2-associated athanogene 4; BCL2-associated athanogene 4; silencer of death domains; SODD
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361167, 67384, 9530
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.06 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O95429, Q8CI61
• Gene Symbols: BAG4
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BAG4 (NP_001191807.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov