Invitrogen™ BAK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120028

Catalog No. PIPA5120028

Description

Positive test controls include: THP-1. The target is usually found in the following locations: Mitochondrion membrane, Single-pass membrane protein. Immunogen sequence: EGVAAPADPE MVTLPLQPSS TMGQVGRQLA IIGDDINRRY DSEFQTMLQH LQPTAENAYE YFTKIATSLF ESGINWGRVV ALLGFGYRLA LHVYQHGLTG F.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Specifications

• Antigen: BAK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BAK1
• Gene Alias: Apoptosis regulator BAK; BAK; Bak1; BAK-LIKE; BCL2 antagonist/killer 1; Bcl2 homologous antagonist/killer; Bcl-2 homologous antagonist/killer; BCL2-antagonist/killer 1; BCL2L7; bcl2-L-7; BCL2-like 7 protein; BCL2-like 7protein; bcl-2-like protein 7; Bcl-2-likeous antagonist/killer; CDN1; MGC117255; MGC3887; N-Bak; N-BAK1; pro-apoptotic protein BAK
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116502, 12018, 578
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 2.11 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O08734, Q16611
• Gene Symbols: BAK1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Bak (NP_0011791).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG