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Banoxantrone dihydrochloride

Catalog No. 421925
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25 mg
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Catalog No. Quantity
42-192-5 25 mg
42-195 5 mg
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Catalog No. 42-192-5 Supplier R&D Systems Supplier No. 4219/25
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Description

Prodrug topoisomerase II inhibitor

Banoxantrone dihydrochloride is a bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC50 >100 μM). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

Specifications

Chemical Name or Material 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride
CAS 252979-56-9
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C22H28N4O6.2HCl
Formula Weight Observed MW: 517.4
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