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MilliporeSigma™ BAP1, Mouse, Unlabeled, Clone: 2A2,

Catalog No. MABE1083 Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABE1083 100 μg Unconjugated
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Catalog No. MABE1083 Supplier MilliporeSigma™ Supplier No. MABE1083

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Description

Mouse Monoclonal Antibody

Serine-protein kinase ATM (EC 2.7.11.1; UniProt Q13315; also known as A-T mutated, Ataxia telangiectasia mutated) is encoded by the ATM (also known as AT) gene (Gene ID 472) in human. Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. Mutation in the ATM gene results in the autosomal recessive disease ataxia telangiectasia (AT). Known ATM substrates include p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1. The S/TQ sequence constitutes the essential substrates phosphorylation site motif. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate phosphorylation, while positively charged residues surrounding the S/TQ are negative determinants. The complex phenotypes of cells derived from patients with AT suggests that ATM has additional cellular substrates. ATM is present as an inactive homodimer or multimer prior to activation. DNA double-stranded breaks induced by ionizing radiation (IR) cause rapid ATM autophosphorylation at Ser1981 in human or the Ser1987 equivalent in mouse.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BAP1
Applications Western Blot
Classification Monoclonal
Clone 2A2
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene BAP1, KIAA0272, hucep-6
Gene Accession No. Q92560
Host Species Mouse
Immunogen Recombinant full-length human BAP1.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_004647
Test Specificity Clone 2A2 targets human BAP1 UCH domain.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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