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Invitrogen™ BAP1 Polyclonal Antibody
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Catalog No. PIPA5110967
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100 μL
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PIPA5110967 100 μL
PIPA5111420 100 μL
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Catalog No. PIPA5110967 Supplier Invitrogen™ Supplier No. PA5110967
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EKYSPKELLA LLKCVEAEIA NYEACLKEEV EKRKKFKIDD QRRTHNYDEF ICTFISMLAQ EGMLANLVEQ NISVRRRQGV SIGRLHKQRK P Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

BRCA1-associated protein-1, or BAP1, interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4. 8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21. 3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BAP1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BAP1
Gene Accession No. Q92560
Gene Alias 2300006C11Rik; AA989761; AW553466; BAP1; Brca1 associated protein 1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; DKFZp686N04275; FLJ35406; FLJ37180; HUCEP-13; hucep-6; KIAA0272; mKIAA0272; Ubiquitin carboxyl-terminal hydrolase BAP1; ubiquitin C-terminal hydrolase X4; UCHL2; uch-x4
Gene Symbols BAP1
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human BAP1. Recombinant protein control fragment (Product #RP-105797).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8314
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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