Invitrogen™ BARD1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5101327	100 μL

Catalog No. PIPA5101327 Supplier Invitrogen™ Supplier No. PA5101327

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total BARD1.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Specifications

• Antigen: BARD1
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: BARD1
• Gene Accession No.: Q99728
• Gene Alias: BARD 1; Bard1; BARD-1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; ENSMUSG00000060893; ENSMUSG00000073653; RING-type E3 ubiquitin transferase BARD1
• Gene Symbols: BARD1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human BARD1(Accession Q99728), corresponding to amino acid residues V298-V348.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 580
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov