Invitrogen™ BARD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560850

Catalog No. PIPA560850

Description

Immunogen sequence: MIQLCSKLRN LLHDNELSDL KEDKPRKSLF NDAGNKKNSI KMWFSPRSKK VRYVVSKASV QTQPAIKKDA SAQQDS Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 67%.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Specifications

• Antigen: BARD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BARD1
• Gene Alias: BARD 1; Bard1; BARD-1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; ENSMUSG00000060893; ENSMUSG00000073653; RING-type E3 ubiquitin transferase BARD1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 580
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q99728
• Gene Symbols: BARD1
• Immunogen: Recombinant protein corresponding to Human BARD1. Recombinant protein control fragment (Product #RP-96098).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG