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Invitrogen™ BARD1 Polyclonal Antibody
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Catalog No. PIPA565149
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100 μL
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PIPA565149 100 μL
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Catalog No. PIPA565149 Supplier Invitrogen™ Supplier No. PA565149
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RRDGPLVLIGS GLSSEQQKML SELAVILKAK KYTEFDSTVT HVVVPGDAVQ STLKCMLGIL NGCWILKFEW VKACLRRKVC EQEEKYEI Highest antigen sequence identity to the following orthologs - mouse 76%, rat 73%.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BARD1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BARD1
Gene Accession No. Q99728
Gene Alias BARD 1; Bard1; BARD-1; BRCA1 associated RING domain 1; BRCA1-associated RING domain gene 1; BRCA1-associated RING domain protein 1; ENSMUSG00000060893; ENSMUSG00000073653; RING-type E3 ubiquitin transferase BARD1
Gene Symbols BARD1
Host Species Rabbit
Immunogen Recombinant Human BARD1. Recombinant protein control fragment (Product #RP-105901).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 580
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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