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BARD1 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 229641AP

Catalog No. 50-173-3973


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Description

Description

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and domit protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Specifications

Specifications

BARD1
0.26 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q99728
BARD 1, BARD1, BRCA1 associated RING domain 1
Rabbit
IgG
150 μL
-20°C
Primary
580
Western Blot
Unconjugated
BARD1
Liquid
BARD1
BARD1 Fusion Protein Ag18965
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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