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Tocris Bioscience™ Baricitinib
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Catalog No. 722250
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72-225-0 50 mg
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Catalog No. 72-225-0 Supplier Tocris Bioscience™ Supplier No. 7222/50
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Description

Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2

Baricitinib is a highly potent JAK1 and JAK2 inhibitor (IC50 values are 5.9 and 5.7 nM, respectively). Also inhibits Tyk2 (IC50 = 53 nM). Displays >100-fold selectivity for JAK1/2 over JAK3 (IC50 = 53 nM for JAK3). Binds AAK1, BIKE, GAK and MPSK1 in vitro (Kd values are 17.2, 39.8, 134.4 and 68.5 nM, respectively). Inhibits IL-6-induced STAT phosphorylation and subsequent pro-inflammatory chemokine (MPC-1) and cytokine (IL-17 and IL-22) production in PBMCs and T-cells. Displays anti-inflammatory and disease modifying effects in the rat adjuvant arthritis model. In silico modelling predicts inhibition of SARS-CoV-2 cell entry.

Specifications

Chemical Name or Material 1-(Ethylsulfonyl)-3-[4-(7 H-pyrrolo[2,3-d]pyrimidin-4-yl)-1 H-pyrazol-1-yl]-3-azetidineacetonitrile
CAS 1187594-09-7
Quantity 50 mg
Target JAK Kinase Inhibitors
Molecular Formula C16H17N7O2S
Purity 0.98
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