Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA547836

Invitrogen™ Basiliximab Chimeric Recombinant Rabbit Monoclonal Antibody (Basiliximab)
GREENER_CHOICE

Catalog No. PIMA547836
Change view
Click to view available options
Quantity:
200 μg
Catalog No. Quantity
PIMA547836 200 μg
1 options

Catalog No. PIMA547836

Supplier: Invitrogen™ MA547836

Only null left
Add to Cart
Add to Cart

Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit-binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (alpha-Beta-gamma-c)-T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.

A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha. Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor. This inhibits IL-2 binding, which inhibits T-cell activation and prevents the body from mounting an immune response against the foreign kidney.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Basiliximab Chimeric
Applications Flow Cytometry, Inhibition Assays, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone Basiliximab
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias CHI621
Host Species Rabbit
Immunogen Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Cynomolgus Monkey, Human, Rhesus Macaque
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.