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Invitrogen™ Bassoon Monoclonal Antibody (SAP7F407)
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Catalog No. MA120689
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50 μg
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MA120689 50 μg
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Catalog No. MA120689 Supplier Invitrogen™ Supplier No. MA120689
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Description

Mouse Monoclonal Antibody

By Western blot, this antibody detects a ~400 kDa band represeneting the Bassoon protein. Additional bands between 97-400 kDa are also identified and are reported to be proteolytic degradation products of Bassoon.

Bassoon is an approximately 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon does not belong to any known protein families. It has been found in rat and mouse with sequence identity of the two proteins at 96%. The human BASSOON gene has recently been cloned and localized. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors. Another presynaptic protein, Piccolo was found to colocalize with Bassoon in cultured hippocampal neurons. These observations suggested that they serve specific functions at synaptic junctions and may be involved in organization of the cytoskeleton at the site of neurotransmitter release.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bassoon
Applications Immunohistochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone SAP7F407
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.1mM PMSF and no preservative
Gene BSN
Gene Accession No. O88737, O88778
Gene Alias bassoon; bassoon (presynaptic cytomatrix protein); bassoon presynaptic cytomatrix protein; BSN; Kiaa0434; neuronal double zinc finger protein; presynaptic cytomatrix protein; protein bassoon; Zinc finger protein 231; ZNF231
Gene Symbols BSN
Host Species Mouse
Immunogen Recombinant rat bassoon fragment (residues 738-1035) expressed asa fusion protein in E.coli.
Purification Method Protein G
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12217, 29138
Target Species Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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