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Invitrogen™ Bassoon Polyclonal Antibody
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Catalog No. PIPA577809
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100 μg
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Catalog No. Quantity
PIPA577809 100 μg
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Catalog No. PIPA577809 Supplier Invitrogen™ Supplier No. PA577809
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Description

Rabbit Polyclonal Antibody

1 μg/mL of PA5-77809 was sufficient for detection of Bassoon in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody. Detects approximately 420kDa. Multiple isoforms can be detected.

Bassoon is an approximately 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon does not belong to any known protein families. It has been found in rat and mouse with sequence identity of the two proteins at 96%. The human BASSOON gene has recently been cloned and localized. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors. Another presynaptic protein, Piccolo was found to colocalize with Bassoon in cultured hippocampal neurons. These observations suggested that they serve specific functions at synaptic junctions and may be involved in organization of the cytoskeleton at the site of neurotransmitter release.
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Specifications

Antigen Bassoon
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene BSN
Gene Accession No. O88737, O88778, Q9UPA5
Gene Alias bassoon; bassoon (presynaptic cytomatrix protein); bassoon presynaptic cytomatrix protein; BSN; Kiaa0434; neuronal double zinc finger protein; presynaptic cytomatrix protein; protein bassoon; Zinc finger protein 231; ZNF231
Gene Symbols BSN
Host Species Rabbit
Immunogen N-terminal his-tagged fusion human protein (AA 786-1041).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12217, 29138, 8927
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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