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Tocris Bioscience™ BAY 1816032
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Catalog No. 754910
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75-491-0 10 mg
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Catalog No. 75-491-0 Supplier Tocris Bioscience™ Supplier No. 7549/10
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Description

Potent and selective BUB1 kinase inhibitor

BAY 1816032 is a potent and selective inhibitor of BUB1 kinase, a mitotic checkpoint serine/threonine kinase (IC50 = 6.1 nM). BAY 1816032 shows 17-fold selectivity over a panel of 403 other human kinases. In vivo, BAY 1816032 decreases tumor size in tumor xenograft models. BAY 181603 is orally bioavailable.

Specifications

Chemical Name or Material 2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1 H-indazol-1-yl]methyl]phenoxy]ethanol
CAS 1891087-61-8
Quantity 10 mg
Target Checkpoint Control Kinase Inhibitors
Molecular Formula C27H24F2N6O4
Purity 0.98
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